ABSTRACT
Cytomegalovirus (CMV) is a double-stranded DNA virus that belongs to the herpesvirus family. In the immunocompetent host, CMV infection is usually mild and goes unnoticed. Patients become prone to CMV infection as a result of immunosuppressive drugs or disorders that weaken cellular immunity. In severe COVID-19 infection, the patient experiences a drop in his T lymphocytes and becomes prone to opportunistic infections such as CMV colitis. In this paper, we presented a rare case of CMV colitis in a 54-year-old female with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) polymerase chain reaction. The patient was admitted to the intensive care unit and intubated due to the severity of her presentation. The patient received high-dose dexamethasone followed by a tapering dose of prednisolone. Fifteen days post-admission, the patient started to have melena with a drop in her hemoglobin. Sigmoidoscopy revealed ulcerated lesions that extended 5 cm proximally, and multiple biopsies confirmed the diagnosis of CMV colitis. The patient was started on ganciclovir 5 mg/kg intravenously for 21 days. The patient's symptoms improved to the point where she no longer complained of melena, and her hemoglobin level normalized. The patient was discharged home in stable condition, to be followed later in the outpatient clinic.